To be fair a lot of them would lead away from the cartoony aspect of City of Heroes/Villains. I know comics did a lot of dark stuff but also a lot of the times villains were either always trying to rob a bank, kill people, cause calamity, take over the world. While in the real world sure villainy would be more dark like prostitution, gambling, drugs etc etc, in a world where a man in spandex bursts through fighting an army of goons with their cape blowing in a building with just their fists is a common sight, idunno. I honestly don't see real world villainy work in this universe nor be a thing that would translate well into an MMO.
City of Heroes hasn't hit the 90s era yet, basically 😛