I just use basic keymapping
Tray 1 is:
1, 2, 3, 4, 5, c, v, Mouse 3, Mouse 4
Tray 2 is:
Shift+1, Shift+2, Shift+3, Shift+4, Shift+5, q, e, r, t,
Tray 3 is:
Well I use the 7 spot on there for "f" key which will be my super travel power
Between those 19 powers, it's easy access for me to do pretty much anything.
My universal abilities are C is my Hybrid power, V is my barrier, Q is always a heal, E is always a self buff, R is always a temporary super defense ability or second self buff, T spacesaver for whatever, Mouse 3 is a localized PBAOE as well as Mouse 4