My opinions:
Interface
Reactive for Damage reduction and Degenerative for -Max HPs seem to be the most popular. Core if you want to lean into the debuff, Radial if you want more damage. I use Diamagnetic on some characters for -To Hit and -Regen. None of the others I tried seemed worth it, unless it's for theme, which is always worth it.
Hybrid
I tried Control on a few controllers and dominators and was underwhelmed. With a group immobilize and a fear power, Radial adds a stun to every attack, but it didn't whelm me. I had Control Core on a Fire/Kin, and the Psionic damage proc seemed nowhere near 75%. The 40% status resistance is nice, if you have concerns.
Unless you are strictly support, Assault is always good; death is the ultimate debuff.
If I can't think of anything, I usually go with Support (and almost always put that on my tankers), Core if I have pets, Radial if not. The end discount, +def, +acc are all nice too.
I rarely use Melee, so I can't be too helpful there. BRB...I just tested Melee Core on an Ill/Kin... 10.7 status protection is sweet, ~16% resist +1% per foe in melee. Regen is OK. Radial (taunts) +1.5 def per foe, 2 status protection per foe (within 10') won't help with AVs without minions.
Now that I've played around on Test Server, I realize I want ALL the Hybrids! And Lores, and Destinies (I usually have a few of those).