Twitch skills I find less important in this game; things seem to stack and overlap, that often when you try and pop an inspiration, computer says no and you're already dead. Trying to predict aggro's land point and spread I find more important. Often trying to do that on an incarnate trial though is akin throwing confetti into the air and trying to catch it all. I got a character to the vet levels without dying (a lot easier now), then stepped into an incarnate trial for the first time and got nuked from orbit.
Oh yeah, the hospital run on this one isn't nice. Then by the time you get half way back, everyone who was alive is now dead and running back from hospital too. And THAT gun toggle. I think the person who designed THAT gun toggle was the same person who designed the character bio editing. With the except of the Lady Gray TF and the mothership raid, you'll probably never have more Rikti attacking you. Why then the only weapon that can hurt the AV and keeps you from using your other powers, takes 12.. 17.. 23 seconds? to untoggle I do not know. I say all those numbers because it seems that it can be any of them and totally random.
Yeah, as other's have mentioned, The Hollows and Independence Port spring to mind. I remember doing the Atta mission where a number of the team were self declared, stoned as hell. It was a team full of scrappers and blasters, I was the only defender and I didn't have recall friend. We got there in the end but it took about five hours.
In the early days, I also remember a guy in The Hollows who repeatedly and impressively crossed the through the middle of the Gulch only to die every single time to the same mob outside the mission entrance. The mob was too high to defeat but not too close to the door. He never moaned, in fact he never said anything 😄