Some of the new sets are really incredible. If you want to deal big damage, bio armor in offensive mode far exceeds every other offensive armor, even ones like fire. However, it also is horrible for defenses in that mode.
Rad armor has amazing resistances with a tiny crash on its to, but gives very little to defense besides a couple aoe debuffs, that mostly affect enemy to hit values, and a single recharge buff based on being surrounded by lots of enemies. If you purely wanna tank hits, theres very little reason not to go Rad.
Rad melee/fire is at 50 a better farmer than spines/fire, but don't tell anyone I said that. What's even better is that rad melee both has just as good of aoe mobbing capability, but also three to four times as good single target, so you arent useless in any boss situation.
That said: titan weapons is still the highest DPS brute/scrapper primary at max. Elec armor is still the best balanced 'kills things fast but also tanks' secondary.
I dont know anything about blaster changes or their new sets, so I can't comment on that side.