Actually, it won't launch any of the five options listed, not even safe mode. I've had this same setup since Homecoming launched and never had a problem before.
I see I now have a Build 011820201 of Island Rum. And my Windows 10 updated last night.
Island Rum launches and operates as expected. When I click the go arrow, I get the checkmark and the usual pause before it closes. Then nothing. No LOADING bar, errors, program, nothing.
There have been no changes since I last played a few days ago. I've restarted the computer twice.