I can't review all the sets as I haven't played them all, but my favorite character is a TW/Rad, so I can comment on those.
TW: Great set at the end game. The set hits like a truck, and just has a fun feel as you swing your giant sword/axe/hammer into things. The downside is that it feels too slow when momentum isn't up, so the leveling process honestly gets pretty painful. Still hits hard, even at low levels, just feels even slower that is already is. Maybe not top tier, but close, and it just feels awesome. So, probably A-tier in execution, but S-tier in bad-assery.
Rad: Love this set. I honestly can't think of a bad thing to say. Great set, and surely top tier for a Brute. S-tier without question.