Since the last forum got wiped, may as well put up a mini guide here on how to run City of Heroes on Linux!
Apparently, you only need to install these two via winetricks to make it all work (from Tequila to the game itself):
winetricks dotnet35 dinput8
Both win32 and win64 prefixes work. Tested on wine 4.6 + esync patches.
So... There you go! Have fun!