I have this same problem. I've tried searching for "Mac + graphics" or other entries on the forum, but basically all of my advanced graphic options are disabled, and it looks horrible on my MAC even tough I have great graphic card. City of Heroes seems to be having issues detecting the MAC graphics card. The options for the game grey out almost all of the advanced graphics options, limiting me to pretty poor graphics settings for the game.
This is what I'm running:
Also, when I check the Activity Monitor, it doesn't look like all of the wine processes are using advanced graphics.
Please, any help is appreciated. Thanks.