I'm pretty sure to hit rolls are higher than average. My main toon is a high level Grav/Kin Controller, which means that hitting things is key to his survivability, and I've made sure his final to hit is clamped at 95%*, even against high level mobs. Thus, I should only be missing 1 out of 20 times, but I'm seeing about twice that against all mobs at all different levels.
Additionally, I have a low level Stalker and have been seeing the same thing there, so I think this is a universal problem and is not limited to hero/villain or a specific class or power set. However, I don't have the time to check every possible permutation. Can anyone else confirm if they are seeing this problem?
* For the record, I know how to calculate the final to hit using Accuracy and ToHit mods, and the numbers in the combat log check out. The problem seems to be with the raw to hit roll.