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I'm currently running a time/beam so I borrowed the beam set up and quickly tossed around the rad part. Keep in mind tohit debuffs = "defense" and you can also boost defense/recharge/status prot ect from p2w vendor. When at 50 its really easy to upkeep the costs of the buffs which last an hour. My time/beam farms 54/8 fairly well I would think Rad wouldn't be any different. I left  2  power slots open, can always move around to fit your needs and concept. I stayed with soul like your original build but I would suggest dark mastery for perma soul drain. The benefit of power boost is very fleeting imho on this build. Hope it helps!

 

Hero Plan by Mids' Reborn : Hero Designer 2.6.1.25
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Level 50 Magic Defender
Primary Power Set: Radiation Emission
Secondary Power Set: Beam Rifle
Power Pool: Speed
Power Pool: Leadership
Power Pool: Leaping
Power Pool: Fighting
Ancillary Pool: Soul Mastery

Hero Profile:
Level 1: Radiant Aura -- Prv-Absorb%(A), Prv-Heal/Rchg/EndRdx(9), Prv-Heal/Rchg(48), Prv-EndRdx/Rchg(50), Prv-Heal/EndRdx(50), Prv-Heal(50)
Level 1: Single Shot -- SprVglAss-Acc/Dmg(A), SprVglAss-Dmg/Rchg(15), SprVglAss-Dmg/EndRdx/Rchg(17), GldJvl-Dam%(17), FrcFdb-Rechg%(19)
Level 2: Radiation Infection -- DarWtcDsp-Rchg/EndRdx(A), DarWtcDsp-ToHitDeb/EndRdx(37), DarWtcDsp-ToHitdeb/Rchg/EndRdx(40), DarWtcDsp-ToHitDeb(48)
Level 4: Cutting Beam -- Ann-Acc/Dmg/EndRdx(A), Ann-ResDeb%(5), AchHee-ResDeb%(7), TchofLadG-%Dam(7), PstBls-Dam%(9)
Level 6: Accelerate Metabolism -- PrfShf-End%(A), PreOptmz-EndMod/Rech(19), PreOptmz-EndMod/End/Rech(23)
Level 8: Enervating Field -- EndRdx-I(A)
Level 10: Disintegrate -- SprDfnBst-Rchg/Heal%(A), SprDfnBst-Acc/Dmg/EndRdx(11), SprVglAss-Rchg/+Absorb(11), SprVglAss-Acc/Dmg/EndRdx(13), SprVglAss-Acc/Dmg/EndRdx/Rchg(13), GldJvl-Dam%(15)
Level 12: Lingering Radiation -- TmpRdn-Acc/EndRdx(A), TmpRdn-EndRdx/Rchg/Slow(34)
Level 14: Super Speed -- Clr-Stlth(A)
Level 16: Hasten -- RechRdx-I(A), RechRdx-I(21)
Level 18: Maneuvers -- LucoftheG-Def/Rchg+(A), GifoftheA-Def/EndRdx(21), GifoftheA-Def(23)
Level 20: Combat Jumping -- LucoftheG-Def/Rchg+(A), Ksm-ToHit+(46)
Level 22: Boxing -- Empty(A)
Level 24: Tough -- UnbGrd-ResDam(A), UnbGrd-ResDam/EndRdx/Rchg(25), UnbGrd-ResDam/EndRdx(25), UnbGrd-EndRdx/Rchg(43)
Level 26: Aim -- GssSynFr--Build%(A), GssSynFr--ToHit/EndRdx(27), GssSynFr--Rchg/EndRdx(27), GssSynFr--ToHit/Rchg/EndRdx(33), GssSynFr--ToHit/Rchg(33), GssSynFr--ToHit(33)
Level 28: Penetrating Ray -- Apc-Dam%(A), Apc-Dmg/EndRdx(29), Apc-Acc/Dmg/Rchg(29), GldJvl-Dam%(31), ExpStr-Dam%(31), StnoftheM-Dam%(31)
Level 30: Weave -- LucoftheG-Def/Rchg+(A), RedFrt-Def(34), RedFrt-Def/EndRdx(34)
Level 32: [Empty] -- Empty(A)
Level 35: Piercing Beam -- Dtn-Dmg/EndRdx/Rng(A), Dtn-Acc/Dmg/EndRdx(36), PstBls-Acc/Dmg/EndRdx(36), PstBls-Dam%(36), JvlVll-Acc/Dmg/End/Rech(37), Bmbdmt-+FireDmg(37)
Level 38: Overcharge -- SprDfnBst-Dmg/Rchg(A), SprDfnBst-Acc/Dmg/EndRdx/Rchg(39), SprDfnBst-Dmg/EndRdx/Rchg(39), Bmbdmt-+FireDmg(39), TchofLadG-%Dam(40), PstBls-Dam%(40)
Level 41: Soul Drain -- SprAvl-Rchg/KDProc(A), SprAvl-Acc/Dmg/EndRdx/Rchg(42), SprAvl-Acc/Dmg(42), SprAvl-Dmg/EndRdx(42), SprAvl-Acc/Dmg/EndRdx(43), SprAvl-Acc/Dmg/Rchg(43)
Level 44: Dark Embrace -- GldArm-3defTpProc(A), StdPrt-ResDam/Def+(45), UnbGrd-Max HP%(45), UnbGrd-ResDam/EndRdx/Rchg(45), UnbGrd-ResDam(46), UnbGrd-ResDam/EndRdx(46)
Level 47: Power Boost -- RechRdx-I(A), RechRdx-I(48)
Level 49: [Empty]
Level 1: Brawl -- Empty(A)
Level 1: Quick Form
Level 1: Prestige Power Dash -- Empty(A)
Level 1: Prestige Power Slide -- Empty(A)
Level 1: Prestige Power Quick -- Empty(A)
Level 1: Prestige Power Rush -- Empty(A)
Level 1: Prestige Power Surge -- Empty(A)
Level 1: Sprint -- Empty(A)
Level 1: Vigilance
Level 2: Rest -- Empty(A)
Level 4: Ninja Run
Level 2: Swift -- Empty(A)
Level 2: Health -- Pnc-Heal/+End(A), NmnCnv-Regen/Rcvry+(3), Mrc-Rcvry+(5)
Level 2: Hurdle -- Empty(A)
Level 2: Stamina -- PwrTrns-+Heal(A), PrfShf-End%(3)
Level 50: Vigor Core Paragon
Level 50: Support Radial Embodiment
Level 50: Ageless Radial Epiphany
Level 0: The Atlas Medallion
Level 0: Task Force Commander
Level 0: Portal Jockey
Level 0: Freedom Phalanx Reserve
------------

 

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Defender - Radiation Emission2 - Beam Rifle.mxd

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