Way I see it, Raphael Firestar (Hero) was one of those "He may be big and tough but is still not sure how to talk to a girl he's attracted to outside of work." types prior to the expedition that changed his life and sent him to the dark side for a while. Even now, long after having seen the light, he's able to amiably flirt and show a gal a good time but is still a bit shy when it comes to actual crushes. One night stands aren't exactly his thing but if he and the lady in question are having a good time... He won't say no that easy. Especially if it's with a woman resembling the one who helped him regain control of his body.
Ra-Akhnaten, the evil priest that took Raphael over, isn't interested in romance in the typical sense. Female 'acolytes', maybe, but he knows most modern women aren't going to go for that without a lot of effort that he doesn't have the time/energy for while retaining control. All he really wanted was to regain his former mystical might and establish himself as the singular ruler [or, failing that, to have a position of power, influence, and worth where he could shape everything].
Raphael Firebane (Praetorian) is also kind of disinterested. He figured that once he held Praetoria get its stuff together under Emperor Cole/Tyrant, he could take the time to untangle seeing his parents killed by the Resistance and free up the emotional and mental energy for that sort of thing. But any relationship he might have had prior to going to Primal Earth might have been a little dysfunctional due to the power and status differences. And how he was in the mindset of "If it's for the good of Praetoria.", "If Marcus says it's for the good of our nation.", or "If it will give me more authority to make Praetoria a better place." before other things.
And Carmilla De Borgia... Well, it's not that she's disinterested. More that after her corruption by the Carnival of Blood, her inherent preferences got overshadowed by the desire to turn young women she finds, much like she herself was converted. At least until she can work through the issues around that and perhaps get a bit like Sister Psyche and Mother Mayhem turned good: having more of a mental relationship of shared thought and feeling, helping other troubled women/former villainnesses to get better, before having a physical connection.