Trying to tighten up a Rad/Bio build, would love some help

I've got a Rad/Bio at 43 right now and am aiming for this for iTrials and 50+ content.

Would appreciate any help on getting my defense up a bit more and getting a handle on my endurance.

Hero Plan by Mids' Hero Designer 1.962

http://www.cohplanner.com/

Click this DataLink to open the build!

Biorad: Level 50 Science Brute

Primary Power Set: Radiation Melee

Secondary Power Set: Bio Armor

Power Pool: Fighting

Power Pool: Leadership

Power Pool: Speed

Power Pool: Leaping

Hero Profile:

Level 1: Contaminated Strike -- SprBlsCol-Dmg/EndRdx/Acc/Rchg(A), SprBlsCol-Acc/Dmg(7), SprBlsCol-Dmg/EndRdx(7), SprBlsCol-Acc/Dmg/EndRdx(9), SprBlsCol-Acc/Dmg/Rchg(9)

Level 1: Hardened Carapace -- UnbGrd-Max HP%(A), UnbGrd-ResDam(3), UnbGrd-ResDam/EndRdx(3), UnbGrd-ResDam/EndRdx/Rchg(13)

Level 2: Inexhaustible -- NmnCnv-Regen/Rcvry+(A), NmnCnv-Heal(11)

Level 4: Environmental Modification -- LucoftheG-Rchg+(A), LucoftheG-Def(5), Rct-ResDam%(34), ShlWal-ResDam/Re TP(46)

Level 6: Boxing -- KntCmb-Acc/Dmg(A), KntCmb-Dmg/EndRdx(11), KntCmb-Dmg/Rchg(13), KntCmb-Dmg/EndRdx/Rchg(15)

Level 8: Proton Sweep -- Arm-Dam%(A), Arm-Dmg/EndRdx(17), Arm-Dmg/Rchg(19), Arm-Acc/Dmg/Rchg(19), Arm-Acc/Rchg(23)

Level 10: Adaptation

Level 12: Fusion -- RechRdx-I(A), RechRdx-I(27)

Level 14: Radiation Siphon -- SprUnrFur-Rchg/+Regen/+End(A), SprUnrFur-Acc/Dmg/EndRdx/Rchg(27), SprUnrFur-Acc/Dmg/Rchg(29), SprUnrFur-Dmg/EndRdx/Rchg(29), SprUnrFur-Acc/Dmg(31)

Level 16: Ablative Carapace -- Prv-Heal/Rchg(A), Prv-Heal/Rchg/EndRdx(17), DctWnd-Heal/EndRdx(21), DctWnd-Heal/Rchg(33)

Level 18: Irradiated Ground -- SprAvl-Rchg/KDProc(A), SprAvl-Acc/Dmg/EndRdx/Rchg(31), SprAvl-Acc/Dmg/Rchg(33), SprAvl-Acc/Dmg/EndRdx(34), SprAvl-Dmg/EndRdx(36), SprAvl-Acc/Dmg(40)

Level 20: Evolving Armor -- GldArm-3defTpProc(A), StdPrt-ResDam/Def+(21)

Level 22: Maneuvers -- LucoftheG-Rchg+(A), LucoftheG-Def(23)

Level 24: Tough -- UnbGrd-ResDam(A), UnbGrd-ResDam/EndRdx(25), UnbGrd-Rchg/ResDam(25), UnbGrd-ResDam/EndRdx/Rchg(36)

Level 26: Devastating Blow -- Hct-Dmg(A), Hct-Dmg/Rchg(42), Hct-Acc/Dmg/Rchg(42), Hct-Acc/Rchg(42), Hct-Dmg/EndRdx(43)

Level 28: DNA Siphon -- Prv-Heal/Rchg/EndRdx(A), Prv-Heal/Rchg(33), DctWnd-Heal/EndRdx(46), DctWnd-Heal/Rchg(48)

Level 30: Weave -- LucoftheG-Rchg+(A), LucoftheG-Def(31)

Level 32: Atom Smasher -- SprBrtFur-Rech/Fury(A), SprBrtFur-Acc/Dmg/EndRdx/Rchg(34), SprBrtFur-Dmg/EndRdx/Rchg(36), SprBrtFur-Acc/Dmg/Rchg(37), SprBrtFur-Dmg/Rchg(37), SprBrtFur-Acc/Dmg(37)

Level 35: Genetic Contamination -- Erd-Acc/Rchg(A), Erd-Acc/Dmg/EndRdx/Rchg(39), Erd-Acc/Dmg/Rchg(39), Erd-Dmg(40)

Level 38: Parasitic Aura -- Prv-Absorb%(A), Prv-Heal/Rchg/EndRdx(39), Prv-Heal/Rchg(40), Prv-Heal(43), Prv-EndRdx/Rchg(45), Prv-Heal/EndRdx(45)

Level 41: Hasten -- RechRdx-I(A), RechRdx-I(43)

Level 44: Combat Jumping -- LucoftheG-Rchg+(A), LucoftheG-Def(45)

Level 47: Tactics -- GssSynFr--Build%(A), GssSynFr--ToHit/EndRdx(48), GssSynFr--Rchg/EndRdx(48), GssSynFr--ToHit/Rchg/EndRdx(50), GssSynFr--ToHit/Rchg(50), GssSynFr--ToHit(50)

Level 49: Super Jump -- WntGif-ResSlow(A)

Level 1: Brawl -- KntCmb-Acc/Dmg(A), KntCmb-Dmg/EndRdx(5), KntCmb-Dmg/Rchg(15), KntCmb-Dmg/EndRdx/Rchg(46)

Level 1: Prestige Power Dash -- Empty(A)

Level 1: Prestige Power Slide -- Empty(A)

Level 1: Prestige Power Quick -- Empty(A)

Level 1: Prestige Power Rush -- Empty(A)

Level 1: Prestige Power Surge -- Empty(A)

Level 1: Fury

Level 1: Sprint -- Empty(A)

Level 2: Rest -- Empty(A)

Level 4: Ninja Run

Level 2: Swift -- Run-I(A)

Level 2: Health -- Pnc-Heal/+End(A)

Level 2: Hurdle -- Jump-I(A)

Level 2: Stamina -- PrfShf-End%(A)

Level 10: Defensive Adaptation

Level 10: Efficient Adaptation

Level 10: Offensive Adaptation

Level 50: Agility Radial Paragon

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Set Bonus Totals:

• 10.5% DamageBuff(Smashing)
  
• 10.5% DamageBuff(Lethal)
  
• 10.5% DamageBuff(Fire)
  
• 10.5% DamageBuff(Cold)
  
• 10.5% DamageBuff(Energy)
  
• 10.5% DamageBuff(Negative)
  
• 10.5% DamageBuff(Toxic)
  
• 10.5% DamageBuff(Psionic)
  
• 32.88% Defense(Smashing)
  
• 32.88% Defense(Lethal)
  
• 12.25% Defense(Fire)
  
• 12.25% Defense(Cold)
  
• 10.38% Defense(Energy)
  
• 10.38% Defense(Negative)
  
• 6% Defense(Psionic)
  
• 33.5% Defense(Melee)
  
• 10.06% Defense(Ranged)
  
• 11% Defense(AoE)
  
• 1.8% Max End
  
• 8.75% Enhancement(Max EnduranceDiscount)
  
• 30% Enhancement(Accuracy)
  
• 68.75% Enhancement(RechargeTime)
  
• 7.5% SpeedFlying
  
• GrantPower Preventive Medicine (10% chance, if Scourge)
  
• 292.4 HP (19.5%) HitPoints
  
• 7.5% JumpHeight
  
• 7.5% SpeedJumping
  
• MezResist(Confused) 83.75%
  
• MezResist(Held) 83.75%
  
• MezResist(Immobilized) 83.75%
  
• MezResist(Sleep) 83.75%
  
• MezResist(Stunned) 83.75%
  
• MezResist(Terrorized) 83.75%
  
• 22.5% (0.38 End/sec) Recovery
  
• 68% (4.25 HP/sec) Regeneration
  
• 50% ResEffect(SpeedFlying)
  
• 50% ResEffect(RechargeTime)
  
• 50% ResEffect(SpeedRunning)
  
• 20.75% Resistance(Smashing)
  
• 35% Resistance(Fire)
  
• 35% Resistance(Cold)
  
• 9.5% Resistance(Energy)
  
• 9.5% Resistance(Negative)
  
• 5% Resistance(Toxic)
  
• 5% Resistance(Psionic)
  
• 0% Resistance(Smashing)
  
• 0% Resistance(Lethal)
  
• 0% Resistance(Fire)
  
• 0% Resistance(Cold)
  
• 0% Resistance(Energy)
  
• 0% Resistance(Negative)
  
• 0% Resistance(Toxic)
  
• 0% Resistance(Psionic)
  
• 20.75% Resistance(Lethal)
  
• 7.5% SpeedRunning
  
• 1 Null
   
   
   
   
  

Well, it looks like it must be a competent build then?

Just bumping once to see if there is anything to critique on this?

Thanks all!

There's a few choices I'd change up but it looks pretty solid! I'd always recommend Musculature and Ageless Incarnate Abilities - once they are tier 4 it adds a big boost to damage and you won't have any Endurance issues.