I just had a thought that a new and possibly very different power set would be grenadier. The set would consist of various types of grenades:
All grenades would have to have some kind of aoe effect (which might be a problem)...
High explosive - smashing/lethal damage only
smoke, low damage plus -acc to enemies
incendiary - fire damage (dot) - possibly set fire to area
flash/bang - low damage, stun, maybe -def
radiation (like in blade), damage (dot) plus debuff
web low/no damage but hold,
but you could also throw multiple grenades in a cone pattern.
It would be amazing if you could somehow grade the damage so the target gets hit hardest and those on the edge of the blast radius get hit least. I think this would have to be a ranged set for blaster/sentinels, defenders etc....
