I had a SS/WP brute in live as wlel, it was an absolute beast. I have no real idea of how Bio will work out when kitted with IO's, but it seems like maybe it has some potential? I just know I don't want to start investing in IO's until I'm sure which one I want to use. This is basically what I've worked out at this point:
WP:
1) Ease of use - Has absolutely no buttons to hit at all if you don't take Resurgence or Strength of Will, and there were plenty of builds that didn't unless you needed one for a specific IO set.
2: Higher regen than Bio (most of the time)
3: Best CC resistances in the game
4: Higher base health buff
5: Has no offensive utility at all
Bio:
1) Comes with -regen and -res for enemies
2) If in efficiency stance has slightly higher recovery than Willpower
3) Has a damage aura
4) When using Ablative Carapace, can get to about 2/3 Willpowers regen. In ideal situations can actually have better regen than Willpower temporarily (when surrounded by enemies, while Parasitic Aura lasts). This is assuming no Enhancements just for easy of checking numbers.
I'm really unsure which one to go with as far as prepping for IO setups. I've got a lot of experience with WP on live and I know it can be come practically immortal, but I have zero experience with bio beyond this server and have yet to see what numbers somebody can really push it into. The -res and -regen make Bio seem like a natural choice if you want to solo AV's, but fighting a prolonged 1v1 battle I feel like WP would sustain itself better than Bio? Really unsure here.