I'm using these powersets on my blaster as well and have been having a pretty good time with it. Overall your build looks pretty good, but I can see a couple places where you might want to make some tweaks.
Firstly, I'd consider dropping charged shot or single shot - maybe not while leveling but certainly once you're at 50. Of the two , I prefer single shot since it's a much faster animation and many have said it does more damage per animation than charged. The reason I say choose one or the other is you'll have better attacks and hopefully enough haste at higher levels that you'll only really need one to fill the very occasional gap in your rotation. For example, when I'm doing single target rotations my highest damage single target ability, Penetrating Ray, is up often enough that I can fire it off every third, sometimes every second shot. The next best single target ability is Lancer Shot.
So on an AV or other single target encounter I'll typically open with melt armour(I'm using the epic fire pool, replace with appropriate debuff as you see fit), disintegrate, chronos, aim, Penetrating Ray, Lancer, and then go into a rotation from there (*Filler, Pen Ray, Lancer) *Filler is just whatever is needed at the time, reapplying melt armour or disintegrate as needed, aim/chronos, bonfire if you use it, piercing shot / single shot depending if there's any secondary targets, any other debuff you might need to reapply.
For AoE I've honestly never had anything weaker than a +4 boss survive an overcharge with Aim and Chronos (and build up) buffing. I'll sometimes use End of Time to hover in and clean up any survivors; if you have space to work that into your build it's a fairly decent PBAoE. Otherwise, disintegrate, lancer for spread, and cutting beam are 'okay' for AoE rotation, but single target is where Beam Rifle does it's best work.
On that note, I'd suggest moving the buildup proc from gaussians into Aim or Chronos - with the PPM thing you'll have the Build Up proc go off almost every time you activate them and it's a LOT easier to maximize the damage potential of build up when you have some control over when you get it, versus having it proc randomly in tactics - but some prefer the hands off approach so that's ultimately up to you; I just find it easier to get those mega-damaging overcharge shots off or big number snipes when I can reliably have build up proc with my opening volley.
Ultimately, I've not found much use for Time Shift or Future Pain, an AoE hold is great, but I'm also using Bonfire with a Knockback to Knockdown enhancement so you may get more mileage out of that. And time stop has worked well as a single target hold without my needing to get into melee.
If you want a look at my build I've attached an older version (I don't have the most recent one with me atm but the changes are mostly minor shifts of one or two enhancement slots and changes to a couple of the sets) It's not a defense/res capped build, but I'm usually flying with a group anyway so my defenses are usually well buffed from other people anyway.
Hope that helped, have fun lasering things!
Blaster - Beam Rifle - Temporal Manipulation.mxd