This is totally do-able, but there are a few caveats.
The hit boxes on giant monsters do tend to stop halfway up or less, doesn't impact most mobs but something to keep in mind.
More importantly, it really depends what your powersets are. Atom Smasher from Rad Melee, the Mighty Judgement attack and Arc of Destruction from TW all require you to be on the ground to activate. Mighty / Atom Smasher let you hover right on the ground but Arc of Destruction flat out does not work if you have hover or flight enabled, which is a bummer.
