Hello Swiz, my PvE recommendations below:
Hybrid: I would suggest Assault double-hit path to maximise your damage, although this may be subject to change with an upcoming patch.
Destiny: Barrier or Rebirth + regeneration for a nice heal and regen, but its also worth picking up Ageless for more recharge depending what situation you are in.
Lore: This is personal preference, but i like Polar Lights for all out damage, unobtrusiveness and they fly.
Interface: Reactive to maximise DPS
Judgement: I like pyronic for the fast animation, but Ion tends to do the most damage overall, although I have no experience with the new Judgements.
Alpha: This depends on your build. I like intuition for damage, however agility cardiac and vigor are also good picks, depending what holes you need to fill in your build.
Hope this helps