I start off with SOs. Things Miracle +recovery, Overwhelming Force, LotG 7.5, PvP SW+5 ref, the+3 def(s), Panacea Proc etc. I slot ASAP like 7, 17, 22 and 27 etc. whatever is the minimum level.
I like slotting attuned with sets unless it is a Hami 50-53, Purple or a PvP I need at 50+5: once I hit somewhere between 22 - 27. For powers that will be using a Hami to cap off the basic numbers, Purples or +5 level 50 PvPs, I just put in the highest Crafted IO 25-45 until 47 and 50.
I like having as many set bonus as possible when I exempt down so everything get attuned that has to be in that +3 level range like 22 for LotG 7.5s.