I have not read the entire thread so I may repeat what other's have already said.
My wish is the set would go all in on the splash mechanic. With a splash of only 8ft, I do not feel these changes would break anything.
Alkaloid - Main target: full heal and full resist, Splash: half heal and half resist. No other changes. It already has low heal numbers and has travel time.
Elixir of Life - Main target: full buffs and full duration, Splash: half buffs and half duration.
Antidote - Main target: full duration, Splash: half duration.
Mostly I want the heal to splash. It feels anemic for team play and is frustrating on Masterminds with mostly melee pets. I know you don't pick Poison if you want healing. But as is, it feels like why bother?