I'm mainly talking about the exact thing you just said. Resist sets are obviously not close to being equal on scrappers and defender because of the resist cap. So, to choose any armor besides the big 3-4 (energy, Bio, stone) is basically nerfing yourself. I get roleplay purposes, but lets be serious here; no one wants to die all the time. Why would I choose Regeneration over Bio armor, besides maybe a theme.