I'll offer a few things I picked up elsewhere.
Judging by leaked set pics, the full Strip is in the show and it was set up for seemingly three different time periods, one pre-war and two post-war. The post-war ones were noticably different in their level of destruction. The most destroyed one is presumably the 'now' of the show. The prior one is, who knows, but still showed definite damage. So possibly/probably pre-NV?
And the plan seems to be to not pick a canon ending to NV and just be ambiguous about it. Bethesda supposedly didn't want them to set anything about NV in stone. So there may be hints, but vague enough that you can make a case for most any of the possible endings. And as it is over 10 years later, no matter the ending, they will write it such that something happened to change it to whatever it is in the 'now' of the show anyhow.
The deathclaw is supposedly a mostly/entirely practical effect and we will supposedly see all of it.