The fact that every CoH hero origin has two allied and two opposing ones made me go like "oh, this must be the mana colors!" So I decided that these were how they must be arranged based on the fact anything else gave me results that I thought were way too weird:
White: Magic
Green: Natural
Red: Technology
Black: Science
Blue: Mutation
Magic in superheroes/comic books is usually like a religious thing, or else literally everything superheroes and villains do would just be "umm, it's magic." Green is natural because, well, it's natural, it's also like "less magic" and they can still use tech, which is red, and tech is like less science. Science on the other hand often balances out religion and is often seen as like this Faustian bargain of progress, though some people can definitely use science and religion, especially the mutants, who are definitely blue. I have to see them as blue because I see science and magic as being way more extreme origins, tech and natural are more down-to-earth, and then mutant is just out there doing its thing and managing to somehow combine science and magic. Also mutation and change in MTG is a blue mechanic, equipping weapons is mostly red, increasing stats is mostly green, doing whatever but there's a cost is mostly black, banding together different beings is mostly white.
The most important thing was preserving the order of the relationships. I can't violate that since that's literally what inspired this. And tech on red would be weird. Making magic and science not be black and white kind of allows some other options, but that kept ending up with magic on green and mutant on white and tech on black and other things that just seemed really weird to me. This is the one where nothing seems obviously weird to me.