Sentinel blast sets get some unique changes in a few places, like Beam Rifle gaining an chain AOE attack (arguably "best" version of BR because of that) and Assault Rifle getting flipped upside down (gets aim, ignite is replaced by single-target incinerator). All of them have their usual mezz attacks like Tesla Cage turned into strong damage attacks (while still keeping the mezz). They all lose sniper attacks in the process though.
Besides that, the different secondaries and AT modifiers might make a set have more synergy with one AT than another, i.e. debuffs from blast sets are stronger on Corr/Def than Blaster, so those sets may have better synergy on a support AT than a pure DPS.
Same goes with armor sets. For example, Sentinel SR gains a passive 30% (enhanceable) recovery, toggle mezz protection (Master Brawler), and a clicky absorb shield (also Master Brawler). Sentinel Invuln is also bonkers because it gets passive +10 max endurance and passively refreshing absorb shield, both in one single auto power. Sents get the best variant of Regen hands down (still kinda meh but a lot more playable).
So basically an AT/build is more than just the sum of its parts. There are synergies and individual differences (when applicable) that can complicate 1:1 comparisons.