I play lots of different Defenders.
I tend to chase all round Defence (but focussed on Ranged) and Recharge (around +100%).
Every Defender benefits from staying alive and having Aim/Nuke up as often as possible.
My generic recipe would be:
6 or 7 primary powers
7 secondary (skip Tier 1 blast and something else not Aim or Nuke)
- Hasten
- Manouvers
- Kick/Tough/Weave
- Combat Jumping or Hover
Defence starts at: Weave (+8), Tough (+6 for two unique IOs), Manouvers (+5.5), CH/Hover (+3 with one LotG) = + 22.5
- In the 40s I'll slot Tough with Unbreakable Guard and get an epic Resistance armor, which usually caps my S/L Resistance
Everything else I slot for Recharge:
- Full set of Defender's Bastion somewhere (+8.75)
- Split Vigilant Assault between two AoE attacks (+12.5)
- Sting of the Manticore (+7.5)
- Basilisks Gaze in any Hold (+7.5)
- LotG in every Defence power, plus 5 Red Fortune in Weave/Manouvers eventually (+22.5 + 10)
- Decimation in one of the blasts (6.25)
- Obliteration in my Nuke (or Bombardment) (+5)
- Prev Medicine full set in a Heal if we have one (+8.75)
Thats about +90% there, which makes Hasten close to perma (we need +110% for that?) bringing you into he realm of 30 second nukes
And Gaussian's proc in Aim, so it nearly always gives you an extra +100% damage on your nuke!
I slot as I go with Attuned enhancements, from around level 22 onwards. By 40 everything's coming together very nicely. And because I'm rich I boost this with P2W buffs all the way to 50, meaning I'm starting at 27.5% Defence to all without ANY contribution from my primary taken into account.
This recipe varies, of course, with powersets.