-to hit debuffs are worthless on AVs.
Let's run some math!
You have a -200 to hit debuff and you are fighting a lvl 54 AV. Right off the bat your -200 to hit debuff is -100 because of the level difference of +4. Then our lovely, and balanced, AV gets to apply, his/her/I'm confused which I am, -87% resistance to the mix leaving your wildly over powered -to hit debuff at a blazing -13 to hit debuff.
Yeah... sad faces all around ;/
So... I may be wrong on the next part but let's reverse the math to find what it would take to get to 45% Defense which should be -45% to hit.
(x/2).13=45 x= -692% to hit debuff is all you need.