Somehow missed the thread at the time, but still replying....
A chunk of being able to stomp on +4/8 is getting your level shift(s) as it drops the relative level of your opponents. Not exactly the answer you were looking for I know, but its part of the equation.
As for an actual build, I will in no way suggest that what I am doing is the end all, be all of SS/Bio building but when I am in a, "I don't want to think about it...I just want to punch things until they drop mood" I do turn to my SS/Bio and he does satisfy. I do not have his current build saved in Mid's, but its not far off from the revised build I am posting:
I would also add that there are some "best practices" that help with surviving nasty situation, like popping Parasitic Aura (even as oddly slotted as I have it) when you run into a suitably large crowd of nasties. Ablative DNA Siphon are your reactive, "Oh crap!" buttons but Parasitic Aura is meant to stop you from getting to, "Oh crap!"