Certainly, lots of combos will work.
I did it a few nights ago with a tank buddy, I was a cold troller. It worked very well and we got through it in 1:17. Afterward we were just chatting about how we could best optimize our little team to beat that time. We're both happy to make new toons specifically for this purpose.
How do you think 2 ill/somethings would work? They have plenty of damage and we could have 2 flavors of debuffs. Maybe ill/rad and ill/dark? The cysts could get tricky without a real tank/brute but maybe it could be mitigated a bit with the extra control.
If we go the tank/brute & debuffer route again, is there a combo that would really compliment one another?
Just looking for a fun way to test ourselves :)