Island Rum didn't change at all, the beta is a completely separate version. I had trouble launching CoH too, it's just being blocked from launching even manually. I'm reasonably sure some part of wine 1.6.5 (part of the Wineskin package) has been blocked as malware by xprotect. I'm going to work on this problem over the weekend and see what I can do.
Mac users having issues launching the game should be aware that this is an Xprotect block issue, nothing changed on our end.