Learning the different enhancement “sets”, their set bonuses, and strategies is complex.
I have no info on your playstyle or favored AT. If a Tank or a Brute there are certain enhancement sets, depending on power sets, that are better. Likewise, if going for a Ranged Defense Blaster there are a few specific enhancement sets you will land on repeatedly. The key is a comprehensive build that 1) actually enhances powers you need enhanced 2) has set bonuses that build to a few build goal targets