I think that when starting out and trying the game, one needs to have in mind what kind of character they want to play before jumping in. I do like stabbity-stabbity, Hulk-smash and the occasional sniper but for the most part I tend to play a lot of support which can be a slog when soloing. Do-able, but you have to take the slow, cautious approach, though when teamed even with a couple other players it can increase the enjoyment considerably.
There are tons of guides for practically every flavour of character you could think of so, I'd suggest starting with what kind of character you'd like to play, tank, scrapper, blaster, blapper, etc. Want to pound on your enemies, blast them in the face, or send your minions after them? The folks here can offer up a multitude of ideas (and have) for a combo of powersets that may fill your needs.