The "very high defenses" is the easy part. There are several valid ways to build a ludicrously tough tank, and most Tanker primaries can be built to insane levels of defense and/or resistance without too much difficulty (some easier than others, of course). The "without exhausting endurance" is what will be tricky. But, you might want to be more specific with your question. When you say "without exhausting endurance", do you mean without the use of a "crash" power like Unstoppable, or do you mean without endurance problems in general?
If what you are looking for is a Tanker primary that is tough enough to fill normal Tanker expectations while not really having to worry much about Endurance, give Electric Armor a look. Power Sink is great.
I see your Powersink via Electric Armor and raise you...
...Dark Consumption in Dark Melee.
No, not instead of, but in addition to. Hear me out.
Pre-shutdown I ran a DM/Elec Brute. I already had a DM/Inv Scrapper from the month CoH was released, hate repeating powerset combinations, and so went Electric Armor instead of the more popular Invulnerability route. Turned out to be an incredibly good choice as on top of having great defenses, self-healing, and area damage you also get to drain the endurance out of your toes and literally are never at a loss for endurance. Sappers? Pfff...no problem. Did I mention that Soul Drain lasts 30s and like Dark Consumption can be slotted with damage enhancements? I probably should have mentioned that.
After I got into playing Tankers the only reason I did not make an Elec/DM Tanker was that old hangups about repeating powerset combos. Given how stupidly survivable the Brute was (and stellar damage output) I am certain the combo will yield a rock solid Tanker.