Once you unlock Incarnate stuff, (or just by hitting level 50), you get 3 total builds available to you. I have a defense-based build using Scorpion's PPP. My 2nd build uses Ghost Widow's PPP and is more resist-focused. I haven't decided on what I want to do with my 3rd build, yet. Regardless, I basically take and use all the kinetics powers, save for repel and inertial reduction, as I want to be able to support my team best, and both speed boost and increase density now buff in an AoE, so it's much easier to buff my entire team all at once. As for IOs, I rarely use the set bonuses, as I'm not as interested in playing the associated meta-game...