@GGInflux The main reason why Rad/SS or Bio/SS are so powerful is because their primaries provide massive Absorb shields that soak a lot of damage, on top of whatever defenses and resists the set may otherwise have.
This allows you to heavily proc out your attacks (primarily Foot Stomp and Knockout Blow, but Gloom and Haymaker are also fair game) so that you're not only doing stupid high damage when stacking Rage, but when you Rage Crash as @Zect mentioned you're still cranking out crazy high damage.
This was observed as early as November 2019, prior to the Tanker buffs. In the current meta, it's one of the all around most powerful and survivable builds possible.
You won't be at any disadvantage.