I have had fantastic results with a radiation armor/savage melee tanker. There are 2 key things I've found with this combination: 1. Do NOT use savage melee attacks that consume your stacks of "blood frenzy", as they apply a recharge and end cost reduction bonus to you. I usually take fighting on these builds, and will mix in an attack with boxing or kick so I lose 1 stack, then use the other powers that consume blood frenzy when it is at 5 stacks, so I keep them instead. 2. Particle Shielding is your bread-and-butter, here. Besides the nice boost to absorb and regen, it also grants a significant recovery boost. While said buff can't be enhanced, if you combine it with stamina, gamma boost, and perhaps a couple of the unique IOs that also grant +end or +recovery, not to mention the aforementioned end cost discount from savage melee's blood frenzy, you are NOT going to tire EVER!!!
A few final notes:
I usually skip maiming strike and hemorrhage. I just don't find that they add enough to my attack chain, and my builds are pretty tight as-is.
I like slotting a fury of the gladiator, chance for -RES in one of the AoE attacks.
Beta Decay, since it applies a def debuff, can accept an achilles' heel, chance for -res as well. Also, while it does not deal any damage itself, can be slotted with something like the perfect
zinger, chance for psionic damage proc.