Uun

You put the Performance Shifter in the right place. If you only have one, it's not that noticeable. In any case, your endurance issues will go away once you get Power Sink at lvl 35. As far as IOs I almost always slot, Steadfast Protection +def, Gladiator's Armor +def, Preventative Medicine +absorb, Gaussian's +BU, Reactive Defenses +resist, Shield Wall + resist, Unbreakable Guard +hp, Kismet +acc, Performance Shifter +end, Numina's +regen/recovery, Regenerative Tissue +regen, Theft of Essence +end.

One of the reasons I often take Quicksand on brutes and tanks.

Kismet +acc isn't a global buff, it has a 120 second duration. If you turn off Hide, you'll lose the buff after 120 seconds. Not sure if you lose it if you're not hidden, but I would move it to one of your shields just to be safe.

Move the Kismet +acc out of Hide to one of your shields. It only works in an active power. Not sure why you're not slotting the 6th piece of Assassin's Mark in Cobra Strike for the 10% recharge bonus. I would slot the full Stalker's Guile set in Assassin's Blow and move the Hetacomb set to Crippling Axe Kick or Crane Kick. Also, you want KB>KD in Crane Kick. Move the Reactive Defense Scaling Resist from Hide to one of your shields, then add the 6th piece for the recharge bonus.

You could switch from Soul Mastery to Dark Mastery. This give you access to Dark Consumption and you get a superior version of Soul Drain (120 sec recharge/15 foot radius vs. 240 sec recharge/10 foot radius).

Beta Decay is the taunt aura. Not skippable.

May not serve to maximize procs, but my preferred slotting for IG is Scirocco's Dervish Acc/Dmg, Acc/Dmg/End, Dmg/End. This provides 47.7% acc, 74.2% dmg and 47.7% endred and leaves 3 slots for procs. If you include the Scirocco's Dervish proc, you also pick up a 9% accuracy bonus.

Already suggested multiple times

The To Hit Debuff, To Hit Debuff/Recharge and To Hit Debuff/Recharge/End Reduction pieces of this set have a level requirement of 7. The Recharge, Recharge/End Reduction and To Hit Debuff/End Reduction pieces have a level requirement of 17. Not sure which is correct, but they should all be the same.

Doesn't help you until the end game, but Hybrid Melee provides protection against Terrorize and Confuse.

If you want to go Mu instead of Fire, you could pick up Power Sink (which has a 2 minute recharge). Granted Ball Lightning is no Fire Ball.

RoP's recharge can't be enhanced.

You're confusing mezz resistance with mezz protection. Resistance shortens the duration. Protection prevents the effect from happening. The set bonus is the former, not the latter.

Read my prior post. LoTG doesn't give you mezz protection as a set bonus.

Not sure what you're talking about. The 5th and 6th slots of LoTG provide S/L and Tx/Psi damage resistance, plus some mezz resistance (reduces mezz duration). There is no set bonus from any set that provides mezz protection.

If you have to resort to pools and incarnates to be survivable, you're playing it wrong. Having perma Particle Shielding is much more useful. You don't mention that it has a big hole to cold damage, which can be an issue fighting BP in end game. I like Rad Armor, but no way is it sturdier than Dark or Electric. Does fine against straight up damage, but folds like a wet noodle when hit with -defense or -regen. I would place it in the C tier. Placing SR in the C tier is absurd. Its definitely sturdier than Willpower or Fire. Not many layers? How about the scaling damage resists that can cap resistance to all damage types. Really doesn't need +absorb or +regen. You do know you can slot other defense sets than LOTG? My SR has none, nor does it have Ageless, Support, Superior Conditioning or Physical Perfection.

If you want to free up some slots (and aren't married to the LOTG bonuses), you can slot each shield with two lvl 50+5 defense IOs. Unless you're doing it for the set bonuses, I wouldn't bother 6-slotting Frostwork. It's a very situational power and is fine with just the base slot. Add slots to Arctic Fog. I usually slot for damage resistance - you can get 30%+ res to F/C/E. You're also want end red. Sleet isn't worth enhancing for damage and is a poor spot for Defender's Bastion. It's fine with two recharge IOs, or 3-4 slot with a defense debuff set. Not sure why you're splitting the Defender's Bastion set. The 3-slot bonus isn't good and you're missing out on substantial defense and recharge bonuses for 6-slotting. 3 recharge IOs in Heat Loss is too many - you're over the ED max. Power Boost doesn't boost the defense in your shields - they're flagged to ignore external boosts. You want Agility Core for your Alpha. Boosts endmod, recharge and defense.

Melee Damage (0.95)

Gamma Boost doesn't need more than the base slot. Beta Decay and Meltdown are fine with 1-2 slots.

I've done them a lot. I prefer all one AT to themed (i.e., all ice). All controller ITF is a lot of fun, as is all blaster.

Have you ever played SR? Definitely belongs in A tier, if not S.

When you exemplar, you have access to powers taken up to 5 levels above your effective level. So if you exemplar to lvl 6, you would have access to powers taken up to lvl 10.

Doubtful. Any AV with the purple triangles (including AVs downgraded to EBs) has 85% resistance to endurance drain. This includes all the AVs required for Portal Jockey, as well as all AVs in TFs and trials. https://hcwiki.cityofheroes.dev/wiki/Archvillain_Resistance

All the story arcs and badge missions you missed are available in Ouro. You (and everyone on the team) will be exemplared to the max level of the arc/mission.

If you skip Proton Sweep (which is terrible), Irradiated Ground is the only AoE Rad Melee gets until Atom Smasher at 38.