The game was played before invention origin enhancements existed and was awesome. Any of the sets that worked then, will work now. Endurance is likely one thing to be mindful of.
General Slotting
Attacks: 2 Accuracy, 3 Damage with an optional End Reduction or Recharge
Defense / Resistance Toggles: 3 Defense or Resistance with 2 End Reduction
Defense / Resistance Autos: 3 Defense or Resistance
Stamina: 2 Endurance
Health: 3 Heal
These may be over slotting in some cases which are easy enough to figure out.
Accuracy and Endurance end up being often overlooked and under slotted.
Having a single origin or standard invention origin build and sprinkling in some unique IOs is also a fun way to play.