CAN you?
Sure.
However you wind up compromising your Defense for a click that renders you mighty for 1/3 of the time...
Granted, the off-clickie Resist values are VERY impressive too.
And, fully saturated Invincibility makes you a BEAST.
Personal preference though is for more steady-state, uniformly high Defense (as a buffer to extreme Def Debuffs)
Again, that's personal preference.
But this build, as I said, is interesting.