@Croax's Stalker thread was an amazing effort and fairly exhaustive. There's been nothing close for Broots.
22 Primaries and 13 Secondaries = nearly 300 combinations
Sprinkle in 8 Patron/Ancillary Power, improved pool powers, plus Incarnates and we're talking thousands of combinations.
Keeping it Simple
Brute intended weakness = endurance
Brute strength = damage cap/boost
Notable = taking hits increases Fury (counter to def cap meta? includes misses)
Play Style
For Brutes, play style preference has a huge influence on any list.
Does the player like combination mechanics in attacks or hate them?
HATE, this shrinks down the list
Does the player like AoE, ST, or both?
Does the player prioritize utility over specialization?
Does the player prefer weapons or not?
Surprisingly, Stone Melee / Fiery Aura (non fire farming) might actually be one the best all-round Brute combinations.
Notables:
Damage toggles in Primaries = Radiation Melee, Ice Melee, Spines
Dark Melee having a heal and +endurance can be very synergistic.