My Method.
I stay away from Tough, Weave and Maneuvers on a tank. Well pretty much any toon I hate wasting power picks on them. Personal Preference. I have only one an Energy Melee/Invul Brute that I went the Tough and Weave route with. It was my most tedious grind. Getting Access to Cross Punch was a good prize at the end of the Fighting Pool Tunnel though.
I take all my Primary Powers and all my Secondary Powers ASAP.
I always take AirSup. Great mitigation.
I take CJ and SJ most always. Sometimes I have to wait a bit to pick up the travel power, so I'll purchase a Jet Pack or a Jet Board.
That leaves plenty of room for a stray pool power something fun, and Ancillary picks.
I rarely have to respec.
This works for my Rad/WM tank, and my Ice/Stone. First is resist, second defense. Ill use this for all my tank builds. Elec/Elec, Fire/Savage coming up next.