Has my big T9 explosion attack recharged yet? OMG it has! Click it you fool, CLICK IT!!
I try and start smart by like clicking a Build Up or something like that, Link Minds, whatever will help my attacks land/protect me, then cut loose with that big AoE or monstrous single target upon my chosen target. Then I get all frantic mashing buttons and whatnot, sometimes with less consideration than I really should be using (clicking a T9 for that white-con minion with only a fraction of Health left wasn't a great choice huh?). When it's all over, hopefully I'm still standing and they are not!
There are some deviations from this based on the powers, such as those commonish attacks that melee types get that don't do too much damage but offer a boost to Defense, I try and reclick those a fair amount, especially if the fight's tough.